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US 6,639,078 B1Granted
Assays for ligands for nuclear receptors
AssigneeSmithKline Beecham Corporation
InventorsCurt Dare Haffner, Patrick Reed Maloney, Timothy Mark Wilson
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Abstract
The present invention includes nuclear receptor heterodimer and nuclear receptor-coactivator pepetide assays for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
Claims2
A compound having the following formula:
- wherein X1 is CH, N;
- X2 is O or NH;
- R and R1 are independently H, lower alkyl, halogen, or CF3;
- R2 is lower alkyl;
- R3 and R4 are independently H, lower alkyl, halogen, CF3, OH, O-alkyl or O-polyhaloalkyl.
2 more elements
Dependencies are inferred from the claim text.