US 6,639,077 B2 · Tri-aryl-substituted-ethane PDE4 inhibitors

Abstract

Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

Dependent claims

A compound represented by

R2 R3 R4 Pyr position n —(CH2)3CF3 CF3 CF3 4-Pyr 1 —CH2(c-Pr) CF3 CF3 4-Pyr 1 —CH(Me)—CCH CF3 CF3 4-Pyr 1 —CHCH2 CF3 CF3 4-Pyr 1 —CH2—CCH CF3 CF3 4-Pyr 1 Me CF3 CF3 4-Pyr 1 c-Pr CF3 CF3 (3,6-diCl)4-Pyr 0 c-Pr CF3 H 4-Pyr 1 c-Pr CF3 CF3 4-Pyr 1 c-Pr CF3 CF3 3-Pyr 0
or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

10/112,535Filed 29 Mar 2002 · continuation in part

Priority

23 Mar 2000

Published

US 2002/0013347 A124 Oct 2002

Granted

28 Oct 2003

Term ends

Not estimatedThe source records don’t support an estimate.

C07D 417/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
C07D
Heterocyclic compounds

Family

Application60/191,668Us provisional application · filed 23 Mar 2000

Application09/810,119Parent of this continuation-in-part · filed 16 Mar 2001

US 2002/0156105 A1Pre-grant publication · published 24 Oct 2002

US 6,399,636 B2Parent of this continuation-in-part

US 2002/0013347 A1Published application

US 6,639,077 B2This patent

From the US filing history. Foreign family members aren’t listed.

Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

Dependent claims

A compound represented by

R2 R3 R4 Pyr position n —(CH2)3CF3 CF3 CF3 4-Pyr 1 —CH2(c-Pr) CF3 CF3 4-Pyr 1 —CH(Me)—CCH CF3 CF3 4-Pyr 1 —CHCH2 CF3 CF3 4-Pyr 1 —CH2—CCH CF3 CF3 4-Pyr 1 Me CF3 CF3 4-Pyr 1 c-Pr CF3 CF3 (3,6-diCl)4-Pyr 0 c-Pr CF3 H 4-Pyr 1 c-Pr CF3 CF3 4-Pyr 1 c-Pr CF3 CF3 3-Pyr 0
or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.