Growth hormone secretagogues

A compound of formula I

• wherein:
• A is C1-C6alkyl, aryl, C1-C6alkylaryl, C1-C6alkyl(O)C1-C6alkylaryl, C1-C6alkyl(S)C1-C6alkylaryl, indolyl, indolinyl, thienyl, (C1-C6alkyl)thienyl, benzothienyl, benzofuranyl, naphthanyl, cyclohexyl, (C1-C6alkyl)indolyl, (C1-C6alkyl)benzothienyl, (C1-C6alkyl)naphthanyl, (C1-C6alkyl)benzofuranyl, and (C1-C6alkyl)cyclohexyl;
• B is NH2, NHR1, C1-C6alkylNH2, C1-C6alkylNHR1, C1-C6alkylarylNH2, C1-C6alkylarylNHR1, C1-C6alkylcyclohexylNH2, C1-C6alkylcyclohexylNHR1, R1-piperidin-3-yl(C1-C6alkyl), R1-piperidin-2-yl(C1-C6alkyl), R1-piperidin-4-yl(C1-C6alkyl), R1-quinolin-2-yl(C1-C6alkyl), R1-(2,4-dihydroquinolin-2-yl(C1-C6alkyl), R1-isoquinolin-2-yl(C1-C6alkyl), and R1-(2,4-dihydroisoquinolin-2-yl(C1-C6alkyl);
• R1 is hydrogen, C1-C6alkyl, C1-C6alkyl(OH), or C1-C6alkylidenyl(OH)R2;
• R2 is C1-C6alkyl, C1-C6alkenyl, C1-C6alkyl(O)C1-C6alkyl, C(O)O—C1-C6 alkyl, aryl, or C1-C6alkylaryl;
• X is C1-C6alkylidenyl, O, S, NH, or N(C1-C6alkyl);
• V is selected from the group consisting of:
• D is —C(O)R6;
• R6 is 1-pyrolidinyl, 1-piperidinyl, 4-methyl-1-piperidinyl,
• E is hydrogen, C1-C6alkyl, C(O)C1-C6alkyl, aryl, (aryl)C(O)NR6, (aryl)(C1-C6alkyl)C(O)R6, C1-C6alkylaryl, C(O)aryl, C1-C6alkylC(O)aryl, naphthyl, C1-C6alkylnaphthyl, C(O)naphthyl, C1-C6alkylC(O)naphthyl, heteroaryl, C1-C6alkylheteroaryl, C(O)heteroaryl, C1-C6alkylC(O)heteroaryl, indanyl, C1-C6alkylindanyl, C(O)indanyl, C1-C6alkylC(O)indanyl, cycloalkyl;
• G is hydrogen, C1-C6alkyl, aryl, C1-C6alkylaryl, and C1-C6alkenyl;
• J is hydrogen, C1-C6alkyl, aryl, and C1-C6alkylaryl;
• L is C1-C6alkyl;
• or a pharmaceutically acceptable salt or solvate thereof.