EST's and encoded human proteins
AssigneeGenset S.A.
InventorsJean-Baptiste Dumas Milne Edwards, Severin Jobert, Jean-Yves Giordano
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Abstract
The sequences of 5′ ESTs and consensus contigated 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs and consensus contigated 5′ ESTs may be used to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs and consensus contigated 5′ ESTs. The 5′ ESTs and consensus contigated 5′ ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5′ ESTs and consensus contigated ESTs. The 5′ ESTs and consensus contigated 5′ ESTs may also be used to design expression vectors and secretion vectors.
Claims20
An isolated, purified, or recombinant polynucleotide encoding a signal peptide, wherein:
- a) the polynucleotide encodes a signal peptide consisting of residues −102 to −1 of SEQ ID NO:
- 3986;
- and
- b) wherein said signal peptide directs the secretion of a polypeptide when located at the amino terminus of a polypeptide.
Dependencies are inferred from the claim text.