Human ADA2 polypeptides
AssigneeHuman Genome Sciences, Inc.
InventorPaul A. Moore
Life of this patent
Estimating the term…
Abstract
Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
Claims48
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues 2 to 443 of SEQ ID NO:13;
- (b) amino acid residues 1 to 443 of SEQ ID NO:13;
- (c) a polypeptide comprising an antigenic fragment of at least 30 contiguous amino acids of SEQ ID NO:13;
- and
- (d) a polypeptide comprising an antigenic fragment of at least 50 contiguous amino acids of SEQ ID NO:13.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length hADA2 polypeptide, excluding the N-terminal methionine residue, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97242;
- (b) the amino acid sequence of the full-length hADA2 polypeptide, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97242;
- (c) a polypeptide comprising an antigenic fragment of at least 30 contiguous amino acids of the hADA2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97242;
- and
- (d) a polypeptide comprising an antigenic fragment of at least 50 contiguous amino acids of the hADA2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97242.
An isolated protein comprising a first amino acid sequence 95% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) amino acid residues 2 to 443 of SEQ ID NO:
- 13;
- (b) amino acid residues 1 to 443 of SEQ ID NO:
- 13;
- (c) a polypeptide comprising at least 30 contiguous amino acids of SEQ ID NO:
- 13,
- wherein said polypeptide regulates gene transcription;
- and
- (d) a polypeptide comprising at least 50 contiguous amino acids of SEQ ID NO:
- 13;
- wherein said polypeptide regulates gene transcription.
An isolated protein comprising a first amino acid sequence 95% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length hADA2 polypeptide, excluding the N-terminal methionine residue, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97242;
- (b) the amino acid sequence of the full-length hADA2 polypeptide, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97242;
- (c) a polypeptide comprising at least 30 contiguous amino acids of the hADA2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97242;
- wherein said polypeptide regulates gene transcription;
- and
- (d) a polypeptide comprising at least 50 contiguous amino acids of the hADA2 polypeptide encoded by the cDNA contained in ATCC Deposit No. 97242;
- wherein said polypeptide regulates gene transcription.
Dependencies are inferred from the claim text.