Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
AssigneeCuris, Inc.
InventorElizabeth A. Wang
Life of this patent
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Abstract
The invention provides methods and compositions for modulating hair growth.
Claims28
A method for promoting growth of hair on skin of a mammal, comprising administering an agent to the mammal for a time and under conditions effective to promote growth of hair on the skin of the mammal, wherein the agent is a hedgehog agonist or a patched antagonist that promotes hedgehog signal transduction, and wherein said hedgehog agonist or patched antagonist promotes hedgehog signal transduction by a mechanism selected from
- (i) binding to patched;
- (ii) altering the binding or enzymatic activity of a protein involved in hedgehog signal transduction;
- or
- (iii) altering expression of a hedgehog protein, a patched protein or a protein involved in hedgehog signal transduction.
A method for promoting growth of hair on skin of a mammal, comprising administering a composition to the mammal for a time and under conditions effective to promote growth of hair on the skin of the mammal, wherein said composition comprises an agent and an acceptable carrier or excipient, and wherein the agent is a hedgehog agonist or a patched antagonist that promotes hedgehog signal transduction, and further said hedgehog agonist or patched antagonist promotes hedgehog signal transduction by a mechanism selected from
- (i) binding to patched;
- (ii) altering the binding or enzymatic activity of a protein involved in hedgehog signal transduction;
- or
- (iii) altering expression of a hedgehog protein, a patched protein or a protein involved in hedgehog signal transduction.
Dependencies are inferred from the claim text.