Cocoa extract compounds and methods for making and using the same
AssigneeMars, Incorporated
InventorsLeo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck, Laurie S. Post, Giovanni G. Cipolla, Craig A. McClelland, Jeff A. Mundt, Harold H. Schmitz
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Abstract
Polyphenol-containing compositions, for example cocoa procyanidin monomer and/or oligomer-containing compositions, and their use inhibiting bacterial growth are disclosed. Compositions may be used for human and veterinary animal administration and may be, for example, in a form of a food, a dietary supplement, or a pharmaceutical.
Claims15
A method of inhibiting bacterial growth in a mammal suffering from, or at risk of, a bacterial infection comprising administering to the mammal a composition comprising an effective amount of a polymeric compound of the formula An, wherein A is a monomer of the following formula:
- wherein n is an integer from 2-18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units;
- R is 3-(α) —OH, 3-(β) —OH, 3-(α)-O-sugar, or 3-(β)-O-sugar;
- bonding between adjacent monomers takes place at positions selected from the group consisting of 4, 6, and 8;
- a bond for additional monomeric unit in position 4 has alpha or beta stereochemistry;
- X, Y, and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to at least one terminal monomeric unit, bonding of the additional monomeric unit thereto is at position 4 and optionally Y═Z=hydrogen;
- the sugar is optionally substituted with a phenolic moiety, and
- pharmaceutically acceptable salts, oxidation products thereof, or combinations thereof.
Dependencies are inferred from the claim text.