Substituted alkylene diamine compounds
AssigneeCV Therapeutics, Inc.
InventorsElfaith Elzein, Jeff Zablocki, Tim Marquart
Life of this patent
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Abstract
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.
Claims21
A substituted alkylene diamine compound having the following formula:
- where R20 is selected from the group consisting of
- wherein m=1 or 2, n=1 or 2, o=0 or 1 or 2;
- R1, R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen and straight or branched C1-15 alkyl;
- R6, R7, R8, R9, R10, R11, and R12 are each hydrogen;
- R13 and R14 are each independently selected from lower alkyl;
- R15, R16, R17, R18, and R19 are each independently selected from the group consisting of hydrogen, halo, and OR23, wherein two adjacent substituents selected from the group consisting of R15, R16, R17, R18, and R19 may together form a ring having from 3 to 4 carbon atoms wherein from 0 to 2 of the carbon atoms may be substituted with an oxygen atom;
- and
- R23 is straight or branched C1-15 alkyl.
A substituted alkylene diamine compound having the following formula:
- wherein R20 is selected from the group consisting of
- wherein m=1;
- n=1;
- o=0 or 1 or 2;
- R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen and straight or branched C1-4 alkyl;
- R6, R7, R8, R9, R10, R11, and R12 are each hydrogen;
- R13 and R14 are each independently selected from straight or branched C1-4 alkyl;
- R15, R16, R17, R18 and R19, are each independently selected from the group consisting of hydrogen, halo, OR23 and straight or branched C1-4 alkyl, or R15 and R16 may together form —CH═CH—CH═CH—, or R16 and R17 may together form —OCH2O—;
- and
- R23 is straight or branched C1-3 alkyl.
A substituted alkylene diamine compound having the following formula:
- wherein R20 is selected from the group consisting of
- wherein m=1;
- n=1;
- o=0 or 1 or 2;
- R1, R2, R, R4 and R5 each independently selected from the group consisting of hydrogen and C1-2 alkyl;
- R6, R7, R8, R9, R10, R11, and R12 are each hydrogen;
- R13 and R14 are C1-2 alkyl;
- and
- R15, R16, R17, R18, and R19 are each independently selected from the group consisting of hydrogen, halo and OR23, or R15 and R16 may together form —CH═CH—CH═CH—, or R16 and R17 may together form —OCH2O—, and
- R23 is straight or branched C1-3 alkyl.
A substituted alkylene diamine compound having the following formula:
- wherein R20 is selected from the group consisting of
- wherein m=1;
- n=1;
- o=1;
- R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are each hydrogen;
- R1 and R5 are each methyl;
- R13 and R14 are C1-2 alkyl;
- R15 is selected from the group consisting of methoxy, hydrogen and Cl, or R15, and R16 may together form —CH═CH—CH═CH—;
- and
- R16, R17, R18, and R19, are each independently selected from the group consisting of hydrogen, or R16 and R17 may together form —OCH2O—.
Dependencies are inferred from the claim text.