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US 6,638,967 B2Granted
Thiophene of furan pyrrolidine compounds
AssigneeOrtho-McNeil Phamraceutical, Inc.
InventorsMichael Bogenstaetter, Wenying Chai, Annette K. Kwok
Life of this patent
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Abstract
Compounds of Formula I Wherein Z2 is an Oxygen or a Sulfur, Z1 is —CH═CH— and Y is a bond, W1 and W2 are hydrogens and X1 and X2 are various heterocyclic rings are disclosed.
Claims7
A compound of formula (I):
- wherein each of W1 and W2 is H;
- X1 is LaGa;
- X2 is LbGb;
- each of Ga and Gb is independently pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidyl, isoindolinyl, morpholinyl, piperazinyl, imidazolyl, thiazolinyl, 5,6-dihydro-3-imidazo[2,1B]-thiazolyl, or thiazolyl;
- Gb can be further selected from pyrrolyl;
- each of La and Lb is independently C1-3 alkylene;
- Y is a covalent bond;
- Z1 is —CH═CH— to form a phenyl ring and Z2 is O or S;
- or a pharmaceutically acceptable salt, amide or ester thereof.
6 more elements
Dependencies are inferred from the claim text.