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US 6,638,966 B2Granted
Use of melatonin analogues for induction of general anesthesia
AssigneeUniversity of Iowa Research Foundation
InventorsMax T. Baker, Mohamed Naguib Attala
Life of this patent
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Abstract
Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
Claims29
An anesthetic composition comprising:
- a pharmaceutically acceptable anesthetic carrier, and an anesthetic inducing effective amount of a 2-trihalomethylmelatonin.
A method of inducing sedative effect as well as general anesthesia, comprising:
- administering to a mammal an effective amount of 2-trihalomethylmelatonin.
An anesthetic composition comprising:
- a pharmaceutically acceptable carrier which is a mixed solvent of 1-methyl-2-pyrrolidinone, propylene glycol and water, and an anesthetic inducing effective amount of 2-trihalomethylmelatonin.
An anesthetic composition comprising:
- a pharmaceutically acceptable anesthetic carrier, and an anesthetic inducing effective amount of 2-phenylmelatonin.
A method of inducing general anesthesia, comprising:
- administering to a mammal an effective amount of a compound selected from the group consisting of 2-bromomelatonin and 2-phenylmelatonin.
An anesthetic composition comprising:
- a pharmaceutically acceptable carrier which is a mixed solvent of 1-methyl-2-pyrrolidinone, propylene glycol and water and an anesthetic inducing effective amount of 2-phenylmelatonin.
Dependencies are inferred from the claim text.