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OwnerJudah Folkman, Harold Brem +1inventors
InventorsJudah Folkman, Harold Brem, H. Paul Ehrlich
Estimating the term…
A method and compositions for inhibiting excessive scar formation and adhesions by administering to a patient in need thereof an effective amount of an angiogenesis inhibitor. In the preferred embodiment, the angiogenesis inhibitor is selective, such as a fumagillol derivative like 0-chloroacetylcarbamoyl-Fumagillol (TNP-470, TAP Pharmaceuticals), thalidomide, or a selective drug having more than one activity, such as minocycline or penicilliamine which also have antibiotic activity. Less selective compounds can also be used, such as the cytokine IL12. Patients to be treated include those having experienced trauma, surgical intervention, burns, and other types of injuries. The inhibitor is administered in an amount effective to decrease excessive scarring, defined as formation of high density tissue including cells and connective tissue, without preventing normal wound closure. The inhibitors can be administered systemically and/or locally or topically, as needed. For prevention of adhesions, the angiogenesis inhibitor would typically be applied at the time of surgery, preferably in a controlled release formulation and/or using barrier technology.
A method to inhibit excessive scar formation and adhesions comprising administering to a patient in need thereof an effective amount of an angiogenesis inhibitor selected from the group consisting of collagenase inhibitors, penicillamine, and IL12.
A method for inhibiting surgical adhesions or burn contractions comprising administering to the site an effective amount of angiogenesis inhibitor selected from the group comprising thalidomide, collagenase inhibitors, penicillamine, and IL12.
A method for inhibiting surgical adhesions or burn contractions comprising administering to the site an effective amount of fumigillin in a pharmaceutically acceptable topical carrier selected from the group consisting of an ointment, gel spray, and paste, for application to a wound.
A composition for application to a wound comprising a polymeric barrier or implant comprising an angiogenesis inhibitor selected from the group comprising thalidomide, fumigillin, collagenase inhibitors, and penicillamine, in a dosage formulation comprising a pharmaceutically acceptable carrier for topical application in an amount effective to prevent or inhibit formation of hypertrophic scars or keloid scars, adhesions or burn contractions.
A composition comprising an angiogenesis inhibitor selected from the group consisting of collagenase inhibitors and penicillamine, in a pharmaceutically acceptable carrier for topical application of the inhibitor selected from the group consisting of an ointment, gel, spray, and paste.
Dependencies are inferred from the claim text.