Yohimbine dimers exhibiting binding selectivities for α2 adrenergic receptors

A compound according to formula (I)

• wherein R is a straight or branched chain alkyl, alkenyl, alkynyl comprising at least 2 carbon atoms in a main chain thereof;
• or
• wherein R is a straight or branched chain alkyl, alkenyl, alkynyl comprising at least 2 carbon atoms in a main chain thereof and an X group within the main chain and/or a Y group as a substituent linked to a carbon atom in the main chain,
• with X being —O—, carbonyl, —NR1— with R1 being H or an alkyl, —C(O)NHR1— with R1 being an alkyl, —S—, sulfoxide, sulfonyl, or a cyclic or multicyclic ring with or without hetero atoms as ring members and including, optionally, one or more substitutions on the ring structure, and
• with Y being —OH, —NO2, —CN, —C(O)H, —SH, a primary, secondary, or tertiary amine, a carboxylic acid, an ester, a keto group, —SO2NH2, or —SO2NHR2 with R2 being an alkyl;
• or
• wherein R is a cyclic or multicyclic ring with or without hetero atoms as ring members and including, optionally, one or more substitutions on the ring structure(s).