2,4-disubstituted triazine derivatives

A compound of formula

• or a N-oxide, a pharmaceutically acceptable salt, or a stereochemically isomeric form thereof, wherein
• —a1═a2—a3═a4— represents a bivalent radical of formula
• —CH═CH—CH═CH— (a-1);
• —N═CH—CH═CH— (a-2);
• —N═CH—N═CH— (a-3);
• —N═CH—CH═N— (a-4);
• or
• —N═N—CH═CH— (a-5);
• n is 0, 1, 2, 3, 4 or 5;
• with the proviso that when n is 5, —a1═a2—a3═a4— is (a-1);
• R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with formyl, C1-6alkylcarbonyl, or C1-6alkyloxycarbonyl;
• and
• each R2 independently is hydroxy, halo, C1-6alkyl optionally substituted with cyano or —C(═O)R4, C3-7cycloalkyl, C2-6alkenyl optionally substituted with one or more halogen atoms or cyano, C2-6alkynyl optionally substituted with one or more halogen atoms or cyano, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR4, —NH—S(═O)pR4, —C(═O)R4, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R4, —C(═NH)R4 or a radical of formula
• wherein
• each A independently is N, CH or CR4;
• B is NH, O, S or NR4;
• p is 1 or 2;
• and
• R4 is methyl, amino, mono- or dimethylamino or polyhalomethyl;
• L is C4-10alkyl, C2-10alkenyl, C2-10alkynyl, or C3-7cycloalkyl, whereby each of said aliphatic groups is optionally substituted with one or two substituents independently selected from
• (i) C3-7cycloalkyl,
• (ii) indolyl or isoindolyl, each optionally substituted with one, two, three or four substituents each independently selected from halo, C1-6alkyl, hydroxy, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, polyhalomethyl, polyhalomethyloxy or C1-6alkylcarbonyl,
• (iii) phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein each of said aromatic rings is optionally substituted with one, two, three, four or five substituents each independently selected from the substituents defined in R2;
• or
• L is —X—R3 wherein
• R3 is phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, wherein each of said aromatic rings is optionally substituted with two, three, four or five substituents each independently selected from the substituents defined in R2;
• and
• X is —NR1—, —NH—NH—, —N═N—, —O—, —C(═O)—, —CHOH—, —S—, —S(═O)— or —S(═O)2—;
• aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl or polyhaloC1-6alkyloxy;
• with the proviso that compounds wherein
• L is —X—R3, X is —NH—;
• R1 is hydrogen;
• —a1═a2—a3═a4— represents a bivalent radical of formula (a-1);
• n is 0 or 1 and R2 is selected from amino or nitro and R3 is phenyl,
• and the compound N,N′-dipyridinyl-(1,3,5)-triazine-2,4-diamine,
• are not included.