Morpholine and thiomorpholine tachykinin receptor antagonists
AssigneeMerck & Co., Inc.
InventorsConrad P. Dorn, Paul E. Finke, Jeffrey J. Hale, Malcolm Maccoss, Sander G. Mills, Shrenik K. Shah, Mark Stuart Chambers, Timothy Harrison, Tamara Ladduwahetty, Brian John Williams
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Abstract
Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
Claims4
A method for the treatment of bladder detrusor hyperreflexia in a mammal in need thereof which comprises administering to the mammal an effective amount of a compound which is:
- or a pharmaceutically acceptable salt thereof.
A method for the prevention of bladder detrusor hyperreflexia in a mammal in need thereof which comprises administering to the mammal an effective amount of a compound which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.