4-dedimethylaminotetracycline derivatives
AssigneeCollaGenex Pharmaceuticals, Inc.
InventorsRobert Ashley, Joseph J. Hlavka
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Abstract
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
Claims10
A 4-de(dimethylamino)doxycycline compound having structure L, M, N, or O.
- wherein R7 is hydrogen, R8 is hydrogen and R9 is acetamido (COL-801).
A 4-de(dimethylamino)doxycycline compound having structure L, M, N or O
- wherein R7 is hydrogen, R8 is hydrogen and R9 is dimethylaminoacetamido (COL-802).
Dependencies are inferred from the claim text.