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US 6,638,908 B1Granted
Crystals of the large ribosomal subunit
AssigneeYale University
InventorsThomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
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AssigneeYale University
InventorsThomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
Estimating the term…
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).
An untwinned crystal of a large ribosomal subunit wherein the crystal comprises an average thickness greater than about 15 μm and diffracts X-rays to a resolution of at least 5 Å.
Dependencies are inferred from the claim text.