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US 6,638,906 B1Granted
Amphiphilic polymers and polypeptide conjugates comprising same
AssigneeNobex Corporation
InventorNnochiri Ekwuribe
Life of this patent
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Abstract
Proteins and/or peptides, such as luminal cholecystokinin releasing factor (LCRF), are conjugated with amphiphilic oligomers and polymers. Such conjugates may modulate the pharmacokinetic profile and/or peptides; thereby improving their clinical utility. Such conjugates may also stabilize and deliver the proteins and/or peptides, such as LCRF, to receptors in the gut without absorption into the bloodstream.
Claims21
A compound of the formula:
- where n is from 3 to 230 and m is from 0 to 20.
A compound of the formula:
- where n is from 3 to 230 and m is from 0 to 20 and X is selected from the group consisting of N, O or S.
A compound of the formula:
- where n is from 3 to 230 and m is from 0 to 20.
A compound of the formula:
- where n is from 3 to 230 and m is from 0 to 20 and X is selected from the group consisting of N, O or S.
A compound comprising:
- a luminal cholecystokinin releasing factor polypeptide comprising a lysine residue;
- an oligomeric moiety attached to the N-terminus of the luminal cholecystokinin releasing factor polypeptide;
- and
- an oligomeric moiety attached to the lysine residue;
- wherein, upon administration to a subject, said compound integrates into a cell membrane of the gut epithelium of the subject, wherein, the luminal cholecystokinin releasing factor polypeptide binds with a target receptor on the epithelial cell surface to provide release of cholecystokinin.
2 more elements
A compound comprising:
- a luminal cholecystokinin releasing factor polypeptide comprising a first lysine residue and a second lysine residue, wherein, the second lysine residue is at the C-terminus of the luminal cholecystokinin releasing factor polypeptide;
- a branched oligomeric moiety attached to the N-terminus of the luminal cholecystokinin releasing factor polypeptide using a non-hydrolyzable linker;
- a linear oligomeric moiety attached to the first lysine residue of the luminal cholecystokinin releasing factor polypeptide using a hydrolyzable bond;
- and
- a linear oligomeric moiety attached to the second lysine residue at the C-terminus of the luminal cholecystokinin releasing factor polypeptide;
- wherein, upon administration to a subject, said compound integrates into a cell membrane of the gut epithelium of the subject, wherein, the luminal cholecystokinin releasing factor polypeptide binds with a target receptor on the epithelial cell surface to provide release of cholecystokinin.
3 more elements
Dependencies are inferred from the claim text.