Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
AssigneeThe Burnham Institute
InventorsJohn C. Reed, Shu-ichi Matsuzawa
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Abstract
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
Claims7
A method of inducing the degradation of the function of a target protein, said method comprising:
- expressing, in a cell, a chimeric protein comprising a target-protein binding domain operatively linked to a protein-degradation binding domain of Siah-1,
- wherein following expression of said chimeric protein the function of the target protein bound by said target-protein binding domain is degraded.
Dependencies are inferred from the claim text.