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US 6,638,731 B2Granted
Human sel-10 polypeptides and polynucleotides that encode them
AssigneePharmacia & Upjohn Company
InventorsMark E. Gurney, Adele M. Pauley, Jinhe Li
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Abstract
The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isolated sel-10 polypeptides and cell lines which express them in which Aβ processing is altered.
Claims80
An isolated double or single stranded nucleic acid molecule wherein said nucleic acid molecule encodes a human sel-10 polypeptide comprising the amino acid sequence of SEQ ID NO:7.
Dependencies are inferred from the claim text.