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US 6,638,729 B2Granted
Use of YLQF, YQEG, YYBQ, and YSXC, essential bacterial genes and polypeptides
AssigneeMillennium Pharmaceuticals, Inc.
InventorsChristian Fritz, Philip Youngman, Luz-Maria Guzman
Life of this patent
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Abstract
Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed “S-ylqF,” “S-yqeG,” “S-yybQ,” “S-yerL,” and “S-ysxC.” These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.
Claims7
A method for determining whether a test compound is a candidate antibacterial agent, the method comprising:
- (a) contacting the test compound with an S-ylqF polypeptide (SEQ ID NO:2);
- and
- (b) detecting binding of the test compound with the polypeptide, wherein binding indicates that the test compound is a candidate antibacterial agent.
Dependencies are inferred from the claim text.