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US 6,638,621 B2Granted
Coated particles, methods of making and using
AssigneeLyotropic Therapeutics, Inc.
InventorDavid Anderson
Life of this patent
Estimating the term…
Abstract
A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix core having at least one a nanostructured liquid phase, or at least on nanostructured liquid crystalline phase or a combination of the two is used for the delivery of active agents such as pharmaceuticals, nutrients, pesticides, etc. The coated particle can be fabricated by a variety of different techniques where the exterior coating is a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material.
Claims107
A coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase or a dehydrated variant thereof,
- ii. at least one nanostructured liquid crystalline phase or a dehydrated variant thereof or
- iii. a combination of
- (1) at least one nanostructured liquid phase or a dehydrated variant thereof and
- (2) at least one nanostructured liquid crystalline phase or a dehydrated variant thereof and
- b. An exterior coating comprising nonlamellar domains.
4 more elements
A coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising nonlamellar domains.
4 more elements
A coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material.
4 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- providing a volume of said matrix that includes at least on chemical species having a moiety capable of forming a nonlamellar material upon reaction with a second moiety and
- contacting said volume with a fluid containing at least one chemical species having said second moiety to react said first moiety with said second moiety and contemporaneously subdividing said volume into particles by the application of energy to said volume.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- providing a volume of said matrix that includes said nonlamellar material dissolved therein and
- causing said nonlamellar material to become insoluble in said matrix and contemporaneously subdividing said volume into particles by the application of energy to said volume.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- providing a volume of said matrix that includes said nonlamellar material dissolved therein and that includes at least one chemical species having a moiety capable of forming said nonlamellar material upon reaction with a second moiety and
- contacting said volume with a fluid containing at least one chemical species having said second moiety to react said first moiety with said second moiety and contemporaneously causing said nonlamellar material to become insoluble in said matrix and subdividing said volume into particles by the application of energy to said volume.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a first nonlamellar material and a second nonlamellar material comprising
- providing a volume of said matrix that includes said first nonlamellar material dissolved therein and that includes at least one chemical species having a moiety capable of forming said second nonlamellar material upon reaction with a second moiety and
- contacting said volume with a fluid containing at least one chemical species having said second moiety to react said first moiety with said second moiety and contemporaneously causing said first nonlamellar material to become insoluble in said matrix and subdividing said volume into particles by the application of energy to said volume.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- dispersing a volume of said matrix in a form of said nonlamellar material selected from the group consisting of liquefied form, solution, or fluid precursor, and
- solidifying said nonlamellar material by a techniques selected from the group consisting of cooling, evaporating a volatile solvent, or implementing a chemical reaction.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- dispersing particles of said matrix into a fluid that includes at least one chemical species having a moiety capable of forming a nonlamellar material upon reaction or association with a second moiety and
- adding to said dispersion at least one chemical species having said second moiety to react said first moiety with said second moiety.
6 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- dispersing particles of said matrix into a fluid that includes at least one chemical species having a moiety capable of forming a nonlamellar material upon reaction or association with a second moiety and
- adding to said dispersion at least one chemical species having said second moiety to react said first moiety with said second moiety and
- subdividing the resulting material into particles by the application of energy to said material.
7 more elements
A method of making a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- dispersing or dissolving a volume of said matrix in a liquid comprising said nonlamellar material in solution or dispersed form and comprising also a volatile solvent, and
- spray-drying said solution or dispersion.
6 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- disposing said particle in a fluid medium comprising an adsorbable material and adsorbing said adsorbable material on said exterior coating.
5 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- disposing said particle in a fluid medium comprising an absorbable material and absorbing said absorbable material in said interior core.
5 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- disposing said particle in a fluid medium comprising an absorbable material and absorbing said absorbable material in said exterior coating.
5 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. An exterior coating comprising a nonlamellar material comprising
- disposing said particle in a fluid medium comprising an absorbable material and absorbing said absorbable material in said interior core and exterior coating.
5 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase, said matrix comprising an active agent disposed therein, and
- b. An exterior coating comprising a nonlamellar material comprising
- disposing said particle in a fluid medium and
- releasing said active agent into said fluid medium.
6 more elements
A method of using a coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least on nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanostructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase, said matrix comprising an active agent disposed therein, and
- b. An exterior coating comprising a nonlamellar material comprising
- releasing said active agent.
5 more elements
A coated particle comprising
- a. an interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanstructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. an exterior coating comprising nonlamellar domains, and
- c. a targeting moiety associated with said coated particle.
5 more elements
A coated particle comprising
- a. an interior core comprising a matrix consisting essentially of
- i. at least one nanostructured liquid phase,
- ii. at least one nanostructured liquid crystalline phase or
- iii. a combination of
- (1) at least one nanstructured liquid phase and
- (2) at least one nanostructured liquid crystalline phase and
- b. an exterior coating comprising nonlamellar domains, and
- c. a bioactive agent associated with said coated particle.
5 more elements
A coated particle comprising
- a. An interior core comprising a matrix consisting essentially of
- i. at least one polymerized nanostructured liquid phase or a dehydrated variant thereof,
- ii. at least one polymerized nanostructured liquid crystalline phase or a dehydrated variant thereof or
- iii. a combination of
- (1) at least one polymerized nanostructured liquid phase or a dehydrated variant thereof and
- (2) at least one polymerized nanostructured liquid crystalline phase or a dehydrated variant thereof and
- b. An exterior coating comprising nonlamellar domains.
4 more elements
Dependencies are inferred from the claim text.