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AssigneeThe Regents of the University of Michigan
InventorsSewon Kang, Gary J. Fisher, John J. Voorhees
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Many human conditions, often skin conditions, are treated topically or orally with a retinoid such as retinoic acid or acetretin, which treatment often has the side effect of dry, irritated, and/or peeling skin. The use of soaps, detergents, chemical irritants, and such can also cause these same side effects. These side effects can be reduced or eliminated by the topical administration of an inhibitor, especially a natural inhibitor, of the epidermal growth factor receptor (EGFR), administered concomitantly with the retinoid, separately from the retinoid (such as on an as needed basis), or both. Administration of the two together is facilitated by a composition suitable for topical application and comprising both the retinoid and a natural EGFR inhibitor. Preferred natural inhibitors are genistein and other isoflavones extracted from natural occurring substances, or simple derivatives of such substances.
A method for diminishing the side effects of reintoid therapy in a patient in need thereof, comprising topically applying to an affected skin area of the pateint a dermatologically suitable composition comprising an effective amount of a natural EGFR inhibitor selected from the group consisting of genistein, genistin, quercetin, equol, staurosporine, aeroplysinin, indocarbazole, lavendustin, piceatannol, kaempferol, daidzein, erbstatin, and tyrphostins, and mixtures thereof and a suitable carrier, wherein the inhibitor is administered to the patient prior to retinoid therapy, during retinoid therapy, and/or after retinoid therapy.
The method of ciaim 11, wherein the retinoid for the retinoid therapy is administered systemically.
Dependencies are inferred from the claim text.