Hyaluronic acid gel composition, process for producing the same, and medical material containing the same
AssigneeDenki Kagaku Kogyo Kabushiki Kaisha
InventorsMasamichi Hashimoto, Toshihiko Umeda, Kazuhiko Arai, Yoshiaki Miyata, Osamu Yamamoto, Yasukazu Himeda
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Abstract
A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.
Claims31
A composition comprising:
- hyaluronic acid and
- a polymer,
- wherein said composition has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C. and
- wherein said composition is produced by a process that does not require the use of cross-liking agents or chemical modifying agents to achieve the percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.
A process for producing a hyaluronic acid gel composition comprising:
- freezing an aqueous solution or dispersion having a pH of 3.5 or lower and comprising hyaluronic acid and a polymer and
- unfeezing said aqueous solution or dispersion to form a hyaluronic acid gel composition.
A process for producing a hyaluronic acid gel composition comprising:
- freezing an aqueous solution having a pH of 3.5 or lower and comprising hyaluronic acid,
- unfreezing said solution to form a hyaluronic acid gel, and
- mixing the hyaluronic acid gel with a polymer or a polymer gel to form a hyaluronic acid gel composition.
A material comprising a hyaluronic acid gel composition which is obtained by irradiating, or injecting, a hyaluronic acid gel composition with at least one member selected from the group consisting of gamma rays, electron rays, plasma and EOG (ethylene oxide gas).
Dependencies are inferred from the claim text.