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US 6,638,537 B2Granted
Microemulsion and micelle systems for solubilizing drugs
AssigneeUniversity of Florida
InventorsDonn M. Dennis, Nikolaus Gravenstein, Jerome H. Modell, Timothy E. Morey, Dinesh Shah
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Abstract
A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprises a long polymer chain surfactant component and a short fatty acid surfactant component, with the amount of each being selected to provide stable microemulsion or micellar systems.
Claims20
A microemulsion drug composition for intravenous delivery comprising:
- an oil phase consisting essentially of at least one drug;
- a long chain polymer surfactant component;
- and
- a short chain fatty acid surfactant component;
- and
- an aqueous phase,
- wherein the amounts of the long chain polymer and short chain fatty acid surfactant components are selected to provide for spontaneous formation of thermodynamically stable microemulsion droplets of the oil phase having a particle size from 10 nm to 100 nm and wherein the interfacial tension of the drug with said emulsifier combination is less than 0.1 dynes per cm.
4 more elements
A method of controlling intravenous drug delivery and transfer rate of drugs comprising:
- preparing microdroplets of the drug with an emulsifier combination of a long chain polymer surfactant component, and a short chain fatty acid surfactant component, the amounts of each being selected to provide for spontaneous formation of thermodynamically stable microemulsion droplets and to control intravenous delivery and transfer rate as desired,
- wherein the drug interfacial tension with the emulsion is less than 0.1 dynes per cm with a droplet size of the active drug in the carrier being less than 100 nm.
Dependencies are inferred from the claim text.