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AssigneeTanabe Seiyaku Co., Ltd.
InventorsTakashi Ishibashi, Hiroaki Kubo, Hiroyuki Yoshino, Masakazu Mizobe
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A preparation capable of releasing a medicinal substance at a targeted site in the intestine, wherein the preparation dose not releases medicinal substance in endogastri at all, but can quickly release a medicinal substance when it reaches the desired site in the intestine after a certain period of time from discharge of the preparation from the stomach, and wherein a core material containing a medicinal substance is coated with a mixed film of a hydrophobic organic compound—an enteric polymer. The preparation is useful for a local therapy of inflammatory disease in the intestine such as ulcerative colitis or Crohn's disease, or an oral administrative therapy with a medicinal substance of a peptide which is apt to be decomposed chemically or enzymatically in any site except for a specific site in the intestine such as the large intestine, or with a medicinal substance whose absorption site in the intestine is limited, or the like, because a medicinal substance can be delivered selectively to a specific site in the intestine.
A unit dose composition capable of quickly releasing a medicinal substance at a targeted site in the intestine, comprising a core material containing a medicinal substance coated with a mixed film consisting essentially of a hydrophobic organic compound and an enteric polymer selected from the group consisting of an enteric acrylic copolymer, an enteric maleic copolymer and an enteric polyvinyl derivative, said mixed film having been deposited from solution, wherein the ratio of hydrophobic organic compound to enteric polymer is within a range of 30:70 to 80:20, and the coating ratio of the mixed film to core material is within a range of 20 to 300% by weight, wherein all of the core material in the composition has a coating with a ratio of hydrophobic organic compound to enteric polymer and a ratio of mixed film to core material which has been preselected so as to result in a product with a predetermined residency at acidic pH without release, and a predetermined residency at neutral or alkaline pH before release so as to quickly release the core material at a predetermined location in the intestinal tract of the subject to whom the composition is to be administered.
A unit dose composition capable of quickly releasing a medicinal substance at a targeted site in the intestine, comprising a core material containing a medicinal substance coated with a mixed film consisting essentially of a hydrophobic organic compound and an enteric polymer, said mixed film having been deposited from solution, wherein the ratio of hydrophobic organic compound to enteric polymer is within a range of 30:70 to 80:20, and the coating ratio of the mixed film to core material is within a range of 20 to 100% by weight, wherein all of the core material in the composition has a coating with a ratio of hydrophobic organic compound to enteric polymer and a ratio of mixed film to core material which has been preselected so as to result in a product with predetermined residency at acidic pH before release so as to quickly release the core material at a predetermined location in the intestinal tract of the subject to whom the composition is to be administered.
A method for preparing a composition capable of releasing a medicinal substance at a targeted site in the intestinal tract of the subject to which the composition is to be administered, comprising:
Dependencies are inferred from the claim text.