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US 6,638,532 B2Granted
Tetracycline—doxycycline antibiotic composition
AssigneeAdvancis Pharmaceutical Corp.
InventorsEdward M. Rudnic, James D. Isbister, Donald J. Treacy, Jr., Sandra E. Wassink
Life of this patent
Estimating the term…
Abstract
An antibiotic product for delivering at least Tetracycline or Doxycycline that is comprised of three dosage forms with different release profiles with each of Tetracycline and Doxycycline being present in at least one of the dosage forms.
Claims66
A once-a-day antibiotic product comprising:
- first, second, and third dosage forms, wherein each of said dosage forms includes at least one antibiotic and a pharmaceutically acceptable carrier;
- one of said dosage forms includes at least a first antibiotic and another of said dosage forms includes at least a second antibiotic that is different from the first antibiotic;
- wherein said first and second antibiotics are each selected from the group consisting of Tetracycline and Doxycycline;
- and wherein when said first antibiotic is Tetracycline said second antibiotic is Doxycycline;
- and wherein when said first antibiotic is Doxycycline said second antibiotic is Tetracycline;
- said first dosage form is an immediate release dosage form;
- said second and third dosage forms are delayed release dosage forms;
- each of said first, second, and third dosage forms initiates release of antibiotic at different times and Cmax in serum of the total antibiotic released from said antibiotic product is achieved in less than about 12 hours from administration;
- and said once-a-day antibiotic product contains the total dosage of said first and second antibiotics for a twenty-four hour period.
6 more elements
A once-a-day antibiotic product comprising:
- first, second, third, and fourth dosage forms, wherein each of said dosage forms includes one of a first antibiotic and a second antibiotic, and a pharmaceutically acceptable carrier;
- wherein said first and second antibiotics are each selected from the group consisting of Tetracycline and Doxycycline;
- and wherein when said first antibiotic is Tetracycline said second antibiotic is Doxycycline;
- and wherein when said first antibiotic is Doxycycline said second antibiotic is Tetracycline;
- wherein the first dosage form contains said first antibiotic and is free of said second antibiotic;
- the second dosage form contains said second antibiotic and is free of said first antibiotic;
- the third dosage form contains said first antibiotic and is free of said second antibiotic;
- and said fourth dosage form contains said second antibiotic and is free of said first antibiotic;
- said first dosage form is an immediate release dosage form;
- said second, third, and fourth dosage forms are delayed release dosage forms;
- each of said first, second, third, and fourth dosage forms initiates release of antibiotic at different times and Cmax in serum of the total antibiotic released from said antibiotic product is achieved in less than about 12 hours from administration;
- and said once-a-day antibiotic product contains the total dosage of said first and second antibiotics for a twenty-four hour period.
9 more elements
Dependencies are inferred from the claim text.