Microemulsion concentrate composition of cyclosporin
AssigneePharmasolutions, Inc.
InventorNirmal Mulye
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Abstract
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of Cyclosporin, in association with a pharmaceutical carrier, said carrier comprising a cyclosporin solubilizing effective amount of a propylene glycol monoester of C6-C18 fatty acid having at least 60% by weight monoester based on the total weight of the propylene glycol ester and a non-ionic surfactant.
Claims21
A pharmaceutical composition comprising a pharmaceutically effective amount of a cyclosporin in association with a pharmaceutical carrier, said carrier comprising (a) a cyclosporin solubilizing effective amount of a propylene glycol ester of C6-C18 fatty acid having at least about 60% by weight of monoester based on the total weight of the propylene glycol ester and (b) a non-ionic surfactant, said non-ionic surfactant being present in an amount sufficient to form a microemulsion with the propylene glycol ester and cyclosporin when brought into contact with an aqueous medium, wherein said cyclosporin is cyclosporin A.
Dependencies are inferred from the claim text.