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US 6,638,521 B2Granted
Oral liquid mucoadhesive compositions
AssigneeThe Procter & Gamble Company
InventorDouglas Joseph Dobrozsi
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AssigneeThe Procter & Gamble Company
InventorDouglas Joseph Dobrozsi
Estimating the term…
The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mixtures thereof and a safe and effective amount of a pharmaceutical active selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, sensory agents, gastrointestinal agents, and mixtures thereof; wherein the composition has a sedimentation volume ratio of greater than about 0.90 and wherein the triggered viscosity ratio of the composition is at least about 1.2. The present invention further relates to a method of coating the alimentary canal and nasal mucosa, in particular to a method of preventing or treating symptoms of upper respiratory tract infections or upper respiratory tract tissue irritation or damage, by administering a safe and effective amount of the above composition.
A method of providing a mucoadhesive coating to mucosa of the esophagus, stomach, and small intestine by swallowing a composition comprising (a) at least two particulate components selected from the group consisting of titanium dioxide, silicon dioxide, and clay, (b) a safe and effective amount of a pharmaceutical active selected from the group consisting of gastrointestinal agents, analgesics, decongestants, expectorants, antitussives, antihistamines, and mixtures thereof, and (c) a pharmaceutically acceptable aqueous oral carrier, wherein the particulate components, in total, are present at a level from about 2% to about 50%, by weight of the composition.
A method of providing a mucoadhesive coating to mucosa of the esophagus, stomach, and small intestine by swallowing a composition comprising (a) at least two particulate components selected from the group consisting of titanium dioxide, silicon dioxide, and clay, (b) a safe and effective amount of a pharmaceutical active selected from the group consisting of gastrointestinal agents, analgesics, decongestants, expectorants, antitussives, antihistamines, and mixtures thereof, and (c) a pharmaceutically acceptable aqueous oral carrier wherein the particulate components, in total, are present at a level from about 2% to about 50%, by weight of the composition, and wherein the composition has a viscosity of less than about 1.5 pascal seconds when swallowed.
A method of providing sustained release and retention of an active agent to mucosa of the esophagus, stomach, and small intestine by mucoadhesively coating said mucosa with a composition comprising (a) at least two particulate components selected from the group consisting of titanium dioxide, silicon dioxide, and clay, (b) a safe and effective amount of the active agent selected from the group consisting of gastrointestinal agents, analgesics, decongestants, expectorants, antitussives, antihistamines, and mixtures thereof, and (c) a pharmaceutically acceptable aqueous oral carrier, wherein the particulate components, in total, are present at a level from about 2% to about 50%, by weight of the composition.
Dependencies are inferred from the claim text.