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AssigneeCorixa Corporation
InventorsSteven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. W. Skeiky, Ajay Bhatia, Rhea N. Coler, Peter Probst, Mark Brannon
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Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
A method for inducing protective immunity against leishmaniasis in a patient comprising administering an immunogenic composition comprising a fusion protein and an immunostimulant, wherein the fusion protein comprises the amino acid sequence of SEQ ID NO:24.
Dependencies are inferred from the claim text.