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US 6,638,516 B1Granted
Strain selection of pneumococcal surface proteins
AssigneeThe UAB Research Foundation
InventorsRobert S. Becker, David E. Briles, Susan Hollingshead
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AssigneeThe UAB Research Foundation
InventorsRobert S. Becker, David E. Briles, Susan Hollingshead
Estimating the term…
The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.
A vaccine or immunogenic composition comprising at least a first isolated immunogenic fragment of PspA and a second isolated immunogenic fragment of PspA from S. pneumoniae strains from at least two PspA families.
The vaccine or immunogenic composition comprising at least a first isolated PspA immunogenic fragment and a second isolated PspA immunogenic fragment from S. pneumoniae strains from at least two PspA families having a C-terminal region of an alpha helix of PspA, wherein the C-terminal region comprises an antigenic epitope of interest.
Dependencies are inferred from the claim text.