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US 6,638,515 B2Granted
Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using protein V
OwnerWalter Schubertinventor
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Abstract
The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using protein V specific for IgG1 and/or IgG3. In one aspect of the invention, protein V blocks the binding of IgG1 and/or IgG3 to the FcγRIII receptor, which inactivates the receptor, and destroys cellular forms containing the receptor.
Claims8
A method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis, said method comprising the steps of:
- (a) detecting for mononucleic cells bearing FcγRIII receptor in a blood sample of said patient;
- and
- (b) administering to said patient an effective amount of protein V, wherein said protein V inhibits the cytotoxic activity of FcγRIII receptor-positive immune cells in said patient and wherein said protein V binds to immunoglobulin G.
Dependencies are inferred from the claim text.