Multivalent dengue virus vaccine
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsKenneth H. Eckels, Joseph R. Putnak, Doria R. Dubois, Bruce L. Innis, Charles H. Hoke, Sun Wellington, Niranjan Kanessa-thasan
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Abstract
The present invention provides vaccine compositions of attenuated dengue virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against all four dengue virus serotypes by administration of attenuated dengue-1, dengue-2, dengue-3, and dengue-4 virus.
Claims12
An immunogenic composition comprising two or more attenuated dengue viruses selected from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-20 having the ATCC accession number VR-2648, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-20 having the ATCC accession number VR-2652, and a physiologically acceptable vehicle.
A multivalent live attenuated dengue virus vaccine comprising any combination of dengue virus serotypes selected from the group consisting of:
- a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-20 having the ATCC accession number VR-2648, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S 16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 strain 341750 PDK-20 having the ATCC accession number VR-2652.
An immunogenic composition comprising two or more attenuated dengue virus chosen from the group consisting of a dengue-1 (DEN-1) virus having the sequence of DEN-1 sawn 45AZ5 PDK-27 having the ATCC accession number PTA4810, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-S0 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH153489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN4) virus having the sequence of DEN-4 strain 341750 PDK6 having the ATCC accession number PTA4811, and a physiologically acceptable vehicle.
A multivalent live attenuated dengue virus vaccine comprising any combination of dengue virus serotypes selected from the group consisting of:
- a dengue-1 (DEN-1) virus having the sequence of DEN-1 strain 45AZ5 PDK-27 having the ATCC accession number PTA4810, a dengue-2 (DEN-2) virus having the sequence of DEN-2 strain S16803 PDK-50 having the ATCC accession number VR-2653, a dengue-3 (DEN-3) virus having the sequence of DEN-3 strain CH53489 PDK-20 having the ATCC accession number VR-2647, and a dengue-4 (DEN-4) virus having the sequence of DEN-4 stain 341750 PDK-6 having the ATCC accession number PTA-4811.
Dependencies are inferred from the claim text.