Mycobacterium polypeptides and nucleic acids encoding them for diagnosis and control of tuberculosis
AssigneeInnogenetics N.V.
InventorsJean Content, Lucas De Wit, Jacqueline De Bruyn
Life of this patent
Estimating the term…
Abstract
The invention relates to nucleic acids which contain particularly a nucleotide sequence extending from the extremity constituted by the nucleotide at position (1) to the extremity constituted by the nucleotide at position (1211) represented on the figure, to the polypeptides coded by the nucleic acids. The polypeptides of the invention can be used for the diagnosis of tuberculosis, and can also be part of the active principle in the preparation of a vaccine against tuberculosis.
Claims17
An isolated polypeptide consisting of a sequence:
- extending from the amino acid at position 1 to the amino acid at position 46 in SEQ ID NO 3;
- extending from the amino acid at position 26 to the amino acid at position 46 in SEQ ID NO 3;
- extending from the amino acid at position 1 to the amino acid at position 340 in SEQ ID NO 3;
- extending from the amino acid at position 126 to the amino acid at position 340 in SEQ ID NO 3;
- SEQ ID NO 5;
- SEQ ID NO 6;
- SEQ ID NO 7;
- SEQ ID NO 16;
- SEQ ID NO 17;
- SEQ ID NO 18;
- SEQ ID NO 19;
- SEQ ID NO 20;
- SEQ ID NO 21;
- SEQ ID NO 22;
- or
- a combination of these sequences.
An immunogenic composition comprising an isolated polypeptide, wherein the polypeptide consists of a sequence;
- extending from the amino acid at position 1 to the amino acid at position 46 in SEQ ID NO 3;
- extending from the amino acid at position 26 to the amino acid at position 46 in SEQ ID NO 3;
- extending from the amino acid at position 1 to the amino acid at position 340 in SEQ ID NO 3;
- extending from the amino acid at position 126 to the amino acid at position 340 in SEQ ID NO 3;
- SEQ ID NO 5;
- SEQ ID NO 6;
- SEQ ID NO 7;
- SEQ ID NO 16;
- SEQ ID NO 17;
- SEQ ID NO 18;
- SEQ ID NO 19;
- SEQ ID NO 20;
- SEQ ID NO 21;
- SEQ ID NO 22;
- or
- a combination of these sequences.
An isolated polypeptide consisting of a sequence:
- encoded by a nucleotide sequence extending from the nucleotide at position (150) to the nucleotide at position (287) in SEQ ID NO:
- 2;
- encoded by a nucleotide sequence extending from the nucleotide at position (224) to the nucleotide at position (287) in SEQ ID NO:
- 2;
- encoded by a nucleotide sequence extending from the nucleotide at position (537) to the nucleotide at position (560) in SEQ ID NO:
- 2;
- encoded by a nucleotide sequence extending from the nucleotide at position (858) to the nucleotide at position (887) in SEQ ID NO:
- 2;
- encoded by a nucleotide sequence extending from the nucleotide at position (972) to the nucleotide at position (1037) in SEQ ID NO:
- 2;
- or
- encoded by a nucleotide sequence extending from the nucleotide at position (1140) to the nucleotide at position (1169) in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.