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US 6,638,510 B1Granted
Recombinant plasmid and a method of controlling the effects of Yersinia pestis
AssigneeBoard of Trustees of Michigan State University
InventorsRobert R. Brubaker, Vladimir L. Motin, George B. Smirnov
Life of this patent
Estimating the term…
Abstract
Described is a plasmid prepared by recombinant techniques which is used to prepare a vaccine against Y. pestis.
Claims4
A method of controlling Y. pestis in a mammal comprising the steps of:
- a) providing a vaccine comprised of an antigen protein encoded by a plasmid prepared by recombinant techniques having the construct shown in FIG. 1;
- and
- b) treating a mammal with an immunologically effective amount of the vaccine.
A method of treating a mammal comprising the steps of:
- a) providing a composition comprised of a protein encoded by a plasmid prepared by recombinant techniques having the construct shown in FIG. 1;
- and
- b) treating a mammal with an effective anti-inflammatory amount of the composition.
A method of immunizing a mammal against Y. pestis comprising the steps of:
- a) providing a composition comprised of the determinants of Y. pestis which have been subjected to a protein encoded by a plasmid prepared by recombinant techniques having the construct shown in FIG. 1;
- and
- b) subjecting the mammal with an effective immunizing amount of the composition.
A method of controlling Y. pestis in a mammal comprising the steps of:
- a) providing a vaccine comprised of a antigen protein encoded by a plasmid prepared by recombinant techniques which plasmid contains low calcium response regions V and H and the structural gene for staphylococcal protein A;
- and
- b) subjecting the mammal with an immunologically effective amount of the vaccine.
Dependencies are inferred from the claim text.