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US 6,638,509 B1Granted
Toxin conjugates
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsToshiyuki Suzawa, Motoo Yamasaki, Satoru Nagamura, Hiromitsu Saito, So Ohta, Nobuo Hanai
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Abstract
The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide.
Claims4
A polyethylene glycol derivative represented by the formula (II):
- X2—CH2(OCH2CH2)nOCH2CO—R1—R2—Y2 (II)
- wherein X2 represents carboxyl, mercapto or
- Y2 represents hydroxyl or
- n is an integer of 1 to 1000, and R1 and R2 are the same or different and each represents an amino acid unit.
1 more element
A polyalkylene glycol derivative represented by the formula:
- X3—(OALK)nO—W0—R1—R2—W2
- wherein ALK represents alkylene;
- n represents an integer of 1-1000;
- W0 represents —CO—, —ALKCO—, or —ALKS—;
- X3 represents HOOCALK—, HISALK—, HOOCOALK—, HOOCNHALK—, HOOCALKCO—,
- R1 and R2, which may be the same or different, each represents an amino acid unit;
- W2 represents —OH, —SH, —OALKCOOH, —NHALKCOOH, —NHALKNH2,
- wherein ALK1 AND ALK2, which may be the same or different, each represents a straight-chain or branched alkylene.
5 more elements
Dependencies are inferred from the claim text.