Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using antibodies to FcγRIII
OwnerWalter Schubertinventor
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using antibodies specific for FcγRIII receptor. In one aspect, the antibody may be a monoclonal antibody. In another aspect, the antibody or the monoclonal antibody may be conjugated with a cytotoxic substance. In a further aspect, the antibody binds to the FcγRIII receptor, inactivates the receptor, and destroys cellular forms containing the receptor.
Claims6
A method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis, said method comprising the steps of:
- (a) detecting for mononucleic cells bearing FcγRIII receptor in a blood sample of said patient;
- and
- (b) administering to said patient an effective amount of an antibody specific for FcγRIII receptor, wherein said antibody inhibits the cytotoxic activity of FcγRIII receptor-positive immune cells in said patient.
Dependencies are inferred from the claim text.