Polyol-IFN-βconjugates modified at Cys-17 and composition containing same
AssigneeApplied Research Systems ARS Holding N.V.
InventorsNabil El-Tayar, Michael J. Roberts, Milton Harris, Wayne Sawlivich
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Abstract
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
Claims5
A polyol-interferon-β conjugate having a polyol moiety covalently bound to Cys17 of human interferon-β.
Dependencies are inferred from the claim text.