Synchronized volumetric fluid balancing systems and methods

A system for volumetrically balancing the supply of ingoing fluid to an individual with the withdrawal of outgoing fluid from the individual comprising a first chamber and a second chamber, each including an interior wall dividing the respective chamber into a first compartment to retain a volume of outgoing fluid and a second compartment to retain a volume of ingoing fluid, the interior wall responding to differential fluid pressure to displace outgoing fluid from the first compartment as ingoing fluid is conveyed into the second compartment and vice versa, a first flow control assembly communicating with a source of outgoing fluid and the first compartments of the first and second chambers, a second flow control assembly communicating with a source of ingoing fluid and the second compartment of the first and second chambers, and a synchronization unit mechanically driving first and second flow control assemblies and operable in a first cycle, during which the first and second flow control assemblies convey a volume of outgoing fluid into the first compartment of the first chamber to displace a volume of ingoing fluid from the second compartment of the first chamber, while conveying ingoing fluid into the second compartment of the second chamber to displace a volume of outgoing fluid from the first compartment of the second chamber, the synchronization unit also being operable in a second cycle, during which the first and second flow control assemblies are driven to convey a volume of ingoing fluid into the second compartment of the first chamber to displace a volume of outgoing fluid from the first compartment of the first chamber, while conveying a volume of outgoing fluid into the first compartment of the second chamber to displace a volume of ingoing fluid from the second compartment of the second chamber, the synchronization unit operating during the first and second cycles to achieve a predetermined volumetric balance between outgoing fluid and ingoing fluid conveyed through the first and second chambers.

A system for volumetrically balancing the supply of ingoing fluid to an individual with the withdrawal of outgoing fluid from the individual comprising a first chamber and a second chamber, each including an interior wall dividing the respective chamber into a first compartment to retain a volume of outgoing fluid and a second compartment to retain a volume of ingoing fluid, the interior wall responding to differential fluid pressure to displace outgoing fluid from the first compartment as ingoing fluid is conveyed into the second compartment and vice versa, a first flow control assembly communicating with a source of outgoing fluid and the first compartments of the first and second chambers, a second flow control assembly communicating with a source of ingoing fluid and the second compartment of the first and second chambers, and a synchronization unit coupled to first and second flow control assemblies being operable in a first cycle, during which the first and second flow control assemblies are commanded to convey a volume of outgoing fluid into the first compartment of the first chamber to displace a volume of ingoing fluid from the second compartment of the first chamber, while conveying ingoing fluid into the second compartment of the second chamber to displace a volume of outgoing fluid from the first compartment of the second chamber, the synchronization unit also being operable in a second cycle, during which the first and second flow control assemblies are commanded to convey a volume of ingoing fluid into the second compartment of the first chamber to displace a volume of outgoing fluid from the first compartment of the first chamber, while conveying a volume of outgoing fluid into the first compartment of the second chamber to displace a volume of ingoing fluid from the second compartment of the second chamber, the synchronization unit operating during the first and second cycles to achieve a predetermined volumetric balance between outgoing fluid and ingoing fluid conveyed through the first and second chambers;

• wherein the synchronization unit includes a drive assembly jointly coupled to the first and second flow control assemblies.

A system for volumetrically balancing the supply of ingoing fluid to an individual with the withdrawal of outgoing fluid from the individual comprising a first chamber and a second chamber, each including an interior wall dividing the respective chamber into a first compartment to retain a volume of outgoing fluid and a second compartment to retain a volume of ingoing fluid, the interior wall responding to differential fluid pressure to displace outgoing fluid from the first compartment as ingoing fluid is conveyed into the second compartment and vice versa, a first flow control assembly communicating with a source of outgoing fluid and the first compartments of the first and second chambers, a second flow control assembly communicating with a source of ingoing fluid and the second compartment of the first and second chambers, and a synchronization unit coupled to first and second flow control assemblies being operable in a first cycle, during which the first and second flow control assemblies are commanded to convey a volume of outgoing fluid into the first compartment of the first chamber to displace a volume of ingoing fluid from the second compartment of the first chamber, while conveying ingoing fluid into the second compartment of the second chamber to displace a volume of outgoing fluid from the first compartment of the second chamber, the synchronization unit also being operable in a second cycle, during which the first and second flow control assemblies are commanded to convey a volume of ingoing fluid into the second compartment of the first chamber to displace a volume of outgoing fluid from the first compartment of the first chamber, while conveying a volume of outgoing fluid into the first compartment of the second chamber to displace a volume of ingoing fluid from the second compartment of the second chamber, the synchronization unit operating during the first and second cycles to achieve a predetermined volumetric balance between outgoing fluid and ingoing fluid conveyed through the first and second chambers;

• wherein the first flow control assembly includes a outgoing fluid inlet passage communicating jointly with the first compartments of the first and second chambers, and a first peristaltic pump unit operatively associated with the outgoing fluid inlet passage, wherein the second flow control assembly includes a ingoing fluid inlet passage communication jointly with the second compartments of the first and second chambers, and a second peristaltic pump unit operatively associated with the ingoing fluid inlet passage, and wherein the synchronization unit includes a drive assembly jointly coupled to the first and second peristaltic pump units.

A system for volumetrically balancing the supply of ingoing fluid to an individual with the withdrawal of outgoing fluid from the individual comprising a first chamber and a second chamber, each including an interior wall dividing the respective chamber into a first compartment to retain a volume of outgoing fluid and a second compartment to retain a volume of ingoing fluid, the interior wall responding to differential fluid pressure to displace outgoing fluid from the first compartment as ingoing fluid is conveyed into the second compartment and vice versa, a first flow control assembly communicating with a source of outgoing fluid and the first compartments of the first and second chambers, a second flow control assembly communicating with a source of ingoing fluid and the second compartment of the first and second chambers, and a synchronization unit coupled to first and second flow control assemblies being operable in a first cycle, during which the first and second flow control assemblies are commanded to convey a volume of outgoing fluid into the first compartment of the first chamber to displace a volume of ingoing fluid from the second compartment of the first chamber, while conveying ingoing fluid into the second compartment of the second chamber to displace a volume of outgoing fluid from the first compartment of the second chamber, the synchronization unit also being operable in a second cycle, during which the first and second flow control assemblies are commanded to convey a volume of ingoing fluid into the second compartment of the first chamber to displace a volume of outgoing fluid from the first compartment of the first chamber, while conveying a volume of outgoing fluid into the first compartment of the second chamber to displace a volume of ingoing fluid from the second compartment of the second chamber, the synchronization unit operating during the first and second cycles to achieve a predetermined volumetric balance between outgoing fluid and ingoing fluid conveyed through the first and second chambers;

• wherein the first flow control assembly includes a first inlet valve assembly controlling flow of outgoing fluid into the first compartments of the first and second chambers, and a first outlet valve assembly controlling flow of ingoing fluid from the second compartments of the first and second chambers, wherein the second flow control assembly includes a second inlet valve assembly controlling flow of ingoing fluid into the second compartments of the first and second chambers, and a second outlet valve assembly controlling flow of outgoing fluid from the first compartments of the first and second chambers, and wherein the synchronization unit includes a drive assembly jointly coupled to the first inlet valve assembly, the first outlet valve assembly, the second inlet valve assembly, and the second outlet valve assembly.

A fluid balancing system for use in a fluid processing procedure during which an outgoing fluid is removed from an individual and an ingoing fluid is supplied to the individual, the system comprising:

• volumetric chamber assembly;
• a first flow assembly communicating with the volumetric chamber assembly for supplying a volume of the outgoing fluid and a volume of the ingoing fluid into the volumetric chamber assembly;
• a second flow assembly communicating with the volumetric chamber assembly for discharging a volume of the outgoing fluid and a volume of the ingoing fluid from the volumetric chamber assembly;
• and
• a synchronization unit driving the first and second flow assemblies causing concurrent discharge of the outgoing fluid and ingoing fluid from the volumetric chamber assembly in volumetric balance with a concurrent supply of outgoing fluid and ingoing fluid into the volumetric chamber assembly.

A fluid balancing system for use with a patient treatment process in which an outgoing fluid is removed from a patient and an ingoing fluid is supplied to the patient, comprising:

• at least one first disposable volumetric chamber connectable to a filter to receive waste fluid from said filter and eject said waste fluid into a waste flow line;
• at least one second disposable volumetric chamber connected to draw from a supply of replacement fluid and eject into a replacement fluid line for supply to a patient;
• a synchronization unit including and operating at least one inlet valve, at least one outlet valve, at least one replacement fluid pump and at least one waste fluid pump synchronously, said synchronization unit being operatively associated with said at least one first volumetric chamber and said at least one second disposable volumetric chamber such that waste fluid received by said first volumetric chamber displaces replacement fluid in said second volumetric chamber, thereby determining a rate at which said replacement fluid is ejected from said second pumping section;
• said synchronization unit being configured such that replacement fluid is delivered continuously during a blood treatment without halting to empty said at least one second disposable pumping chamber.

A fluid balancing system for use with a patient treatment process in which an outgoing fluid is removed from a patient and an ingoing fluid is supplied to the patient, comprising:

• first and second fluid circuits each with waste and replacement fluid volumetric chambers connected hermetically to respective connectors for waste fluid withdrawal from a waste fluid source and waste fluid disposal and for replacement fluid withdrawal from a supply and infusion to a patient;
• a mechanical synchronization unit including at least one pump;
• said first and second fluid circuit waste and replacement fluid volumetric chambers each having flexible walls;
• valves controlling flow of fluid into and out of said volumetric chambers;
• said synchronization unit being configured to operate said valves such that during a first cycle, waste fluid filling said first fluid circuit waste volumetric chamber displaces replacement fluid in said first fluid circuit replacement fluid volumetric chamber as replacement fluid filling said second fluid, circuit replacement fluid volumetric chamber displaces waste fluid in said second fluid circuit waste volumetric chamber and during a second cycle waste fluid filling said second fluid circuit waste volumetric chamber displaces replacement fluid in said second fluid circuit replacement fluid volumetric chamber as replacement fluid filling said first fluid circuit replacement fluid volumetric chamber displaces waste fluid in said first fluid circuit waste volumetric chamber.

A fluid balancing system for use with a patient treatment process in which an outgoing fluid is removed from a patient and an ingoing fluid is supplied to the patient, comprising:

• a disposable fluid circuit including flexible wall portions defining at least one waste fluid chamber and at least one replacement fluid chamber;
• a drive mechanism including a pump engageable with said fluid circuit such that waste fluid may be pumped into said at least one waste fluid chamber;
• said drive mechanism operating valves synchronously such that replacement fluid is extracted from said at least one replacement fluid chamber in equal volume increments as said at least one waste fluid chamber is filled;
• said drive mechanism being configurable to engage said disposable fluid circuit and reconfigurable for conducting said patient treatment process.

A system for volumetrically balancing the supply of ingoing fluid to an individual with the withdrawal of outgoing fluid from the individual comprising a first chamber and a second chamber, each including an interior wall dividing the respective chamber into a first compartment to retain a volume of outgoing fluid and a second compartment to retain a volume of ingoing fluid, the interior wall responding to differential fluid pressure to displace outgoing fluid from the first compartment as ingoing fluid is conveyed into the second compartment and vice versa, a first flow control assembly communicating with a source of outgoing fluid and the first compartments of the first and second chambers, a second flow control assembly communicating with a source of ingoing fluid and the second compartment of the first and second chambers, and a synchronization unit coupled to first and second flow control assemblies being operable in a first cycle, during which the first and second flow control assemblies are commanded to convey a volume of outgoing fluid into the first compartment of the first chamber to displace a volume of ingoing fluid from the second compartment of the first chamber, while conveying ingoing fluid into the second compartment of the second chamber to displace a volume of outgoing fluid from the first compartment of the second chamber, the synchronization unit also being operable in a second cycle, during which the first and second flow control assemblies are commanded to convey a volume of ingoing fluid into the second compartment of the first chamber to displace a volume of outgoing fluid from the first compartment of the first chamber, while conveying a volume of outgoing fluid into the first compartment of the second chamber to displace a volume of ingoing fluid from the second compartment of the second chamber, the synchronization unit operating during the first and second cycles to achieve a predetermined volumetric balance between outgoing fluid and ingoing fluid conveyed through the first and second chambers;

• wherein the synchronization unit is operable in a transition cycle between the first and second cycles, and wherein, during the transition cycle, the synchronization unit operates the first and second flow control assemblies to prevent flow of both outgoing and ingoing fluids into the respective first and second compartments.

A fluid balancing system for use with a patient treatment process in which an waste fluid is removed from a patient and an replacement fluid is supplied to the patient, comprising:

• a fluid circuit with volumetric chambers;
• a blood treatment device with a replacement fluid pump, a waste fluid pump, and a motor;
• said blood treatment machine including valves operatively associated with said fluid circuit;
• said blood treatment machine being configured such that said replacement fluid pump and said waste fluid pump are mechanically interlocked, such that said waste fluid is moved into at least one of said volumetric chambers displacing replacement fluid in at least another of said volumetric chambers, and driven synchronously by said motor;
• said fluid circuit being removable from said blood treatment device.