Optical sensors for the detection of nitric oxide
AssigneeThe Regents of the University of Michigan
InventorsRaoul Kopelman, Heather Clark, Susan Barker
Life of this patent
Estimating the term…
Abstract
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity. Additionally, metals functionally linked to reporter dyes are described in addition to the incorporation of reference compounds for ratiometric measurements.
Claims23
An optical fiber comprising a fiber tip, said tip comprising an immobilized nitric oxide-binding compound and a fluorescent reference compound.
Dependencies are inferred from the claim text.