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US 6,635,776 B2Granted
Lipoxin compounds and their use in treating cell proliferative disorders
AssigneeThe Brigham and Women's Hospital, Inc.
InventorCharles N. Serhan
Life of this patent
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Abstract
Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.
Claims18
A pharmaceutical composition comprising a compound of the structural formula:
- wherein X is OR1;
- wherein R1 is
- (i) a hydrogen atom;
- or
- (ii) an alkyl of 1 to 8 carbon atoms, inclusive, which may be straight chain or branched;
- wherein Q1 is (C═O);
- wherein Q3 is O;
- wherein R2, R3, and R4 are each hydrogen atoms;
- wherein Y1 or Y2 is —OH and the other is H;
- wherein R5 is —RaQaRb wherein Qa═—O—;
- wherein Ra is an alkylene of 0 to 6 carbon atoms, inclusive, which may be straight chain or branched;
- wherein Rb is either an alkyl of 0 to 8 carbon atoms, inclusive, which may be straight chain or branched or a substituted phenyl;
- wherein R6 is a hydrogen atom;
- and
- a pharmaceutically acceptable carrier.
12 more elements
Dependencies are inferred from the claim text.