N-benzhydryl indole compounds

A compound of the formula

• wherein
• R is —(CH2)n—A, —(CH2)n—S—A, or —(CH2)n—O—A, where A represents:
• D represents C1-C6 alkyl, C1-C6 alkoxy, —CF3 or —C1-3alkyl—CF3, B and C are each independently selected from the group consisting of phenyl, pyridinyl, pyrimidinyl, furanyl, thiophenyl or pyrrolyl groups, each optionally substituted by from 1 to 3, substituents selected independently from the group consisting of H, halogen, —CN, —CHO, —CF3, —OCF3, —OH, —C1-C6 alkyl, C1-C6 alkoxy, —NH2 , —N(C1-C6)2, —NH(C1-C6), —N—C(O)—(C1-C6), —NO2, or by a 5- or 6-membered heterocyclic or heteroaromatic ring containing 1 or 2 heteroatoms selected from O, N or S;
• R′ is selected from the group consisting of —CH2—OH, —CH2—NH—S(O)2—(CH2)n2-halo, —CH2—NH—S(O)2—CH═CH, —CH2—NH2, or a protected form of —CH2—NH2;
• R7 and R8 are independently selected from H, halogen, —CN, —CHO, —CF3, —OCF3, —OH, —C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, —NH2, —N(C1-C6)2, —NH(C1-C6), —N—C(O)—(C1-C6), or —NO2;
• R9 represents —(CH2)n4—CO2H, a C1-C8 alkyl ester of —CH2)n4—CO2H, or a pharmaceutically acceptable acid mimic or mimetic;
• R10 is selected from H, halogen, —CN, —CHO, —CF3, —OCF3, —OH, —C1-C6 alkyl, C1-C6 alkoxy, C1—C6 thioalkyl, —NH2, —N(C1-C6)2, —NH(C1-C6), —N—C(O)—(C1—C6), or —NO2;
• R11 is selected from H, halogen, —CN, —CHO, —CF3, —OCF3, —OH, —C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, —NH2, —N(C1-C6)2, —NH(C1-C6), —N—C(O)—(C1-C6), —NO2, —N—C(O)—N(C1-C3 alkyl)2, —N—C(O)—NH(C1-C3 alkyl), —N—C(O)—O—(C1-C3 alkyl), —SO2—C1-C6 alkyl, —S—C3-C6 cycloalkyl, —S—CH2-C3-C6 cycloalkyl, —SO2-C3-C6 cycloalkyl, , —SO2—CH2—C3-C6 cycloalkyl, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, —O—C3-C6 cycloalkyl, , —O—CH2—C3-C6 cycloalkyl, phenyl, benzyl, benzyloxy, morpholino, pyrrolidino, piperidine, piperizine, furan, thiophene, imidazole, tetrazole, pyrazine, pyrazolone, pyrazole, imidazole, oxazole or isoxazole, the rings of each of these groups each being optionally substituted by from 1 to 3 substituents selected from the group of H, halogen, —CN, —CHO, —CF3, —OH, —C1-C6 alkyl, C1-C6 alkoxy, —NH2, —N(C1-C6)2, —NH(C1-C6), —N—C(O)—(C1-C6), —NO2, —SO2(C1-C3 alkyl), —SO2NH(C1-C3 alkyl), —SO2N(C1-C3 alkyl)2, or OCF3;
• n is an integer from 0 to 3;
• n, is an integer from 0 to 3;
• n2 is an integer from 0 to 3
• n3 is an integer from 0 to 3;
• n4 is an integer from 0 to 2;
• and,
• X is a linking group selected from the group consisting of of —O—, —CH2—, —SO2—, —NH—, and
• —N(C1-C6-alkyl)—.