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US 6,635,753 B1Granted
Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
AssigneeBrantford Chemicals Inc.
InventorsBruno K. Radatus, K. S. Keshava Murthy
Life of this patent
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Abstract
There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates, Stavudine NN dimethylacrylamide solvates and Stavudine NN dimethylpropionamide solvates which results in pure Stavudine.
Claims31
A compound as a precipitated solvate selected from the group consisting of:
- a) Stavudine N,N-dimethylacetamide solvate;
- b) Stavudine N,N-dimethylacrylamide solvate;
- and
- c) Stavudine N,N-dimethylpropionamide solvate.
1 more element
A pharmaceutical composition comprising Stavudine having a purity of at least 99.5% in a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.