B7-H2 nucleic acids, members of the B7 family
AssigneeMillennium Pharmaceuticals, Inc.
InventorsAnthony J. Coyle, Christopher C. Fraser, Stephen Manning
Life of this patent
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Abstract
B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
Claims47
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1;
- b) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:3;
- c) a nucleic acid comprising the cDNA insert of the plasmid deposited with ATCC as Accession Number 2085,
- d) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:4;
- e) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence encoded by the cDNA insert of the plasmid deposited with ATCC as Accession Number 2085.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1, or the complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:3, or the complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in the cDNA insert of the plasmid deposited with ATCC as Accession Number 2084, or the complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in the cDNA insert of the plasmid deposited with ATCC as Accession Number 2085, or the complement thereof.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:4, or the complement thereof.
Dependencies are inferred from the claim text.