Pharmaceutical composition for treating fecal incontinence
AssigneeS.L.A. Pharma AG
InventorsMichael A. Kamm, Robin K. S. Phillips
Life of this patent
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Abstract
Fecal incontinence and anal itch can be treated by administration, more particularly by local application to the anus, of an a adrenergic blocker, nitric oxide synthase inhibitor, prostaglandin F2α, dopamine, morphine, β-blockers, and 5-Hydroxytryptamine. The patients who benefit most from the invention are those who have a normal or low maximum anal resting pressure and a structurally intact internal anal sphincter muscle, and patients who have had major bowel resection and reanastomisis.
Claims7
A method for the treatment of fecal incontinence comprising topically administering in and/or around the anal canal of a patient, a topical composition comprising 5% w/w to 50% w/w of phenylephrine or a pharmacologically acceptable salt thereof in an amount effective to increase the internal anal sphincter pressure.
Dependencies are inferred from the claim text.