Pharmaceutical preparations for external use containing non-steroidal anti-inflammatory and analgesic agents
AssigneeBristol-Myers Squibb Company
InventorsTeruhisa Kaneko, Yuka Shinohara, Yoko Kawamura, Masaaki Nagase
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Abstract
The present invention relates to an anti-inflammatory and analgesic pharmaceutical preparation for external use having excellent percutaneous absorption and applicability. The pharmaceutical preparations for external use of this invention comprise NSAIDs and, as a percutaneous absorption promoting agent, oleic acid, oleyl alcohol or a mixture thereof, in a pharmaceutically acceptable aqueous alcoholic solvent comprised of a monohydric saturated aliphatic alcohol of 1-4 carbon atoms, a polyhydric alcohol selected from the group consisting of saturated aliphatic glycols of 2-4 carbon atoms and glycerol, and water.
Claims13
An anti-inflammatory analgesic pharmaceutical topical composition comprising
- (a) an anti-inflammatory and analgesic effective amount of a non-steroidal anti-inflammatory and analgesic agent;
- (b) a skin penetration enhancer selected from the group consisting of oleic acid, oleyl alcohol and mixtures thereof, the enhancer being present in an amount sufficient to enhance skin penetration of the non-steroidal anti-inflammatory and analgesic agent, as compared to a like composition that does not contain the enhancer;
- and
- (c) a pharmaceutically acceptable vehicle for the non-steroidal anti-inflammatory and analgesic agent and the skin penetration enhancer consisting of 15 to 70 weight %, based on the total weight of the composition, of a monohydric saturated aliphatic alcohol containing 1 to 4 carbon atoms;
- 0.1 to 30 weight %, based on the total weight of the composition, of a polyhydric alcohol selected from the group consisting of saturated aliphatic glycols containing 2 to 4 carbon atoms and glycerol;
- and 10 to 60 weight %, based on the total weight of the composition, of water.
Dependencies are inferred from the claim text.