Agent for lowering prolactin
AssigneeBionorica AG
InventorsWolfgang Wuttke, Hubertus Jarry, Michael Popp, Volker Christoffel, Barbara Spengler
Life of this patent
Estimating the term…
Abstract
The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane or clerodane type: wherein R1=H, C1 to C3 alkyl or C1 to C3 acyl.
Claims12
A prolactin lowering drug comprising at least one bicyclic diterpene compound of the clerodane type in accordance with at least one of general formulae (III) or (IV):
- wherein R1=H, C1 to C3 alkyl or C1 to C3 acyl;
- wherein the rings A and/or B in the case of general formulae (III) or (IV) are optionally substituted in position 1, 2, 3, 4, 6, 7, or 8 with at least one OX radical, with X=H, C1 to C3 alkyl or C1 to C3 acyl;
- wherein optionally at least one carbon atom in position 17, 18, 19 and 20 is substituted with an OX radical, with X=H, C1 to C3 alkyl or C1 to C3 acyl;
- wherein optionally at least one CH3 group in position 17, 18, 19 and 20 is replaced by one COOH group;
- wherein optionally at least one of ring positions 1, 2, 3, 6, or 7 is a keto group;
- and
- wherein optionally at least one double bond is present in ring positions 1, 2, 3, 6, 7, 8, 8(17) of formula (III);
- and
- wherein optionally at least one double bond is present in ring positions 1, 2, 3, 4(18), 6, 7, 8, 8(17) of formula (IV);
- with the exception of the following compounds:
- (+) hardwickiic acid, crolechinic acid, and hautriwaic acid.
Cleroda-Y, 14-dien-13-ol, wherein Y=ring positions 1, 2, 6, 7 or 8(17).
Cleroda-Y,Z, 14-trien-13-ol, wherein Y or Z=ring position 1, 3, or 1, 4(18) or 1, 6 or 1, 7 or 1, 8(17) or ring position 2, 4(18) or 2, 6 or 2,7 or 2, 8(17) or ring position 4(18), 6 or 4(18), 7 or 4(18), 8(17) or ring position 6, 8(17).
Dependencies are inferred from the claim text.