Isomeric fused pyrrolocarbazoles and isoindolones

A compound of Formula I:

• or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein:
• ring D is selected from phenyl and cyclohexene with double bond a-b;
• ring B and ring F, independently, and each together with the carbon atoms to which they are attached, are selected from a 6-membered carbocyclic ring;
• G—X—W is selected from:
• a) —(A1A2)C—N(R1)—C(B1B2)—;
• b) —CH(R1A)—C(═O)—N(R1)—;
• and
• c) —N(R1)—C(═O)—CH(R1A)—;
• R1 is selected from:
• a) H, substituted or unsubstituted alkyl of 1 to 6 carbons, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroarylalkyl;
• b) —C(═O)R7, where R7 is selected from substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted carbocyclic group, and substituted or unsubstituted heterocyclyl groups;
• c) —OR8, where R8 is selected From H and alkyl having from 1 to 6 carbons;
• d) —C(═O)NHR8, —NR9R10, —(CH2)pNR9R10, —(CH2)pOR8, —O(CH2)pOR8 and —O(CH2)pNR9R10, where p is from 1 to 4;
• and where either
• 1) R9 and R10 are each independently selected from H, unsubstituted alkyl of 1 to 6 carbons, and substituted alkyl;
• or
• 2) R9 and R10 together form a linking group of the formula —(CH2)2—X1—(CH2)2—, wherein X1 is selected from —O—, —S—, and —CH2—;
• R1A is the same as R1;
• R2, R3, R4 and R5 are each independently selected from:
• a) H, aryl, carbocyclyl, heterocyclyl, —CN, CF3, —NO2, —OH, —OR7, Br, I, —O(CH2)pNR9R10, —OC(═O)R7, —OC(═O)NR9R10, —O(CH2)pOR8, F, Cl, —CH2OR8, —NR9R10, —NR8S(═O)2R7, —NR8C(═O)R7, or —NR8C(═S)R7;
• b) —CH2OR11, where R11 is the residue of an amino acid after the hydroxyl group of the carboxyl group is removed;
• c) —NR8C(═O)NR9R10, —NR8C(═S)NR9R10, —CO2R12, —C(═O)R12, —C(═O)NR9R10, —C(═S)NR9R10, —CH═NOR12, —CH═NR7, —(CH2)pNR9R10, —(CH2)pNHR11, or —CH═NNR12R12A;
• where
• R12 is selected from H, alkyl of 1 to 6 carbons, —OH, alkoxy of 1 to 6 carbons, —OC(═O)R7, —OC(═O)NR9R10, —OC(═S)NR9R10, —O(CH2)pNR9R10, —O(CH2)pOR8, substituted or unsubstituted arylalkyl having from 6 to 10 carbons, substituted or unsubstituted heterocyclylalkyl, and a substituted or unsubstituted carbocyclic group;
• R12A is the same R12;
• d) —S(O)yR12, —(CH2)pS(O)yR7, —CH2S(O)yR11 where y is 0, 1 or 2;
• e) alkyl of 1 to 8 carbons, alkenyl of 2 to 8 carbons, and alkynyl of 2 to 8 carbons, wherein:
• 1) each alkyl, alkenyl, or alkynyl group is unsubstituted;
• or
• 2) each alkyl, alkenyl or alkynyl group is substituted with 1 to 3 groups selected from aryl of 6 to 10 carbons, heterocyclyl, arylalkoxy, heterocycloalkoxy, hydroxylalkoxy, alkytoxy-alkoxy, hydroxyalkylthio, alkoxy-alkylthio, F, Cl, Br, I, —CN, —NO2, —OH, —OR7, —X2CH2)pC(═O)NR9R10, —X2(CH2)—C(═S)NR9R10, —X2(CH2)pOC(═O)NR9R10, —X2(CH2)pCO2R7, —X2(CH2)pS(O)yR7, —X2(CH2)pNR8C(═O)NR9R10, —OC(═O)R7, —OC(═O)NHR12, O-tetrahydropyranyl, —NR9R10, —NR8CO2R7, 13 NR8C(═O)NR9R10, —NR8C(═S)NR9R10, —NHC(═NH)NH2, —NR8C(═O)R7, —NR8C(═S)R7, —NR8S(═O)2R7, —S(O)yR7, —CO2R12, —C(═O)NR9R10, —C(═S)NR9R10, —C(═O)R12, —CH2OR8, —CH═NNR12R12a, —CH═NOR12, —CH═NR7, —CH═NNHCH(N═NH)NH2, —S(═O)2NR12R12A, —P(═O)(OR8)2, and —OR11, and a monosaccharide of 5 to 7 carbons where each hydroxyl group of the monosaccharide is independently either unsubstituted or is replaced by H, alkyl of 1 to 4 carbons, alkylcarbonyloxy of 2 to 5 carbons, or alkoxy of 1 to 4 carbons;
• X2is O, S, or NR8;
• Q is selected from —NR6;
• R6 is selected from —H, —SO2R7, —CO2R7, —CO(═O)R7, —C(═O)NR9R10, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, and alkynyl of 2-8 carbons;
• and either
• 1) each alkyl, alkenyl, or alkynyl group is unsubstituted;
• or
• 2) each alkyl, alkenyl, or alkynyl group independently is substituted, as defined for R2, R3, R4, and R5 in e) above;
• Y is selected from:
• a) an unsubstituted alkylene of 2 carbons;
• b) an alkylene of 2 carbons substituted with R13, where R13 is selected from R2thioalkyl of 1-4 carbons, halogen, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, and alkynyl of 2-8 carbons, where
• i) each alkyl of 1-8 carbons, alkenyl of 2-8 carbons, and alkynyl of 2-8 carbons is unsubstituted;
• or
• ii) each alkyl of 1-8 carbons, alkenyl of 2-8 carbons, and alkynyl of 2-8 carbons, independently, is substituted, as defined for R2, R3, R4, and R5 in e) above;
• and
• c) a functional group selected from —CH═CH—, —CH(OH)—CH(OH)—, —C═C(R13)2—, —C(═O)CH(R6)—, —CH(R6)C(═O)—, —C(═NOR12)CH(R6)—, —CHR8C(═NOR12)—, —CH2Z—, —ZCH2—, where Z is selected from —C(R12)—;
• A1 and A2 are selected from H, H;
• H, OR12;
• H, —SR12;
• H, —N(R12)2;
• and a group where A1 and A2 together form a moiety selected from ═O, ═S, and ═NR12;
• and,
• B1 and B2 are selected from H, H;
• H, —OR12;
• H, —SR12;
• H, —N(R12)2;
• and a group where B1 and B2 together form a moiety selected from ═O, ═S, and ═NR12;
• with the proviso that at least one of the pairs A1 and A2, or B1 and B2, form ═O.