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US 6,635,661 B2Granted
Heterocyclic analgesic compounds and methods of use thereof
AssigneeSepracor Inc.
InventorsGregory D. Cuny, Liming Shao, James R. Hauske, Michele L. R. Heffernan, Brian M. Aquila, Xinhe Wu, Fengjiang Wang, Thomas D. Bannister
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Abstract
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-coupled receptors, and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds as analgesics.
Claims26
A compound represented by G:
- wherein
- R represents phenyl, 2-fluorophenyl, 3-fluorophenyl, or 4-fluorophenyl;
- R′ represents H or OH;
- and
- the stereochemical configuration at any stereocenter of a compound represented by G is R, S, or a mixture of these configurations.
2 more elements
Dependencies are inferred from the claim text.