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US 6,635,656 B1Granted
Cytotoxic alkaloids halitulin
AssigneePharma Mar, S.A.
InventorsYoel Kashman, Ganit Koren-Goldshlager, Maria Dolores Garcia Gravalos, Michael Schleyer
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Abstract
Compounds of general formula (I), wherein the nature of the group R is not particularly critical and typically takes various forms, include the natural compound halitulin of formula (I) and have antitumor activity.
Claims2
A halitulin compound of formula
- or a pharmaceutically acceptable acid addition salt thereof.
A method of preparation of halitulin, which comprises:
- (a) extraction of compounds from tissue of the sponge Haliclona tulearensis using a suitable solvent, and
- (b) separation of halitulin from the extracted compounds by chromatography.
Dependencies are inferred from the claim text.