Therapeutic uses of di-aryl acid derivatives

A compound of formula (I)

• wherein:
• is oxazolyl or quinolinyl, which are optionally substituted by one or more ring system substituents;
• is phenyl, which is optionally substituted by one or more ring system substituents, in addition to being substituted by group Z;
• B and E are a chemical bond;
• a is 1;
• b is 0 or 1;
• c is 0;
• d is 0;
• g is 1-5;
• R1, R2, R3 and R4 are, independently, hydrogen, halogen or alkyl, wherein alkyl is optionally substituted by one or more alkyl group substituents;
• Z is R21O2C—, R21OC—, —CN, R21O2SHNCO—, R21O2SHN—, (R21)2NCO— or R21O—;
• R21 is independently
• hydrogen,
• alkyl, which is optionally substituted by one or more alkyl group substituents,
• aryl, which is optionally substituted by one or more ring system substituents,
• cycloalkyl, which is optionally substituted by one or more ring system substituents, or
• aralkyl, wherein the aryl portion is optionally substituted by one or more ring system substituents and the alkyl portion is optionally substituted by one or more alkyl group substituents;
• R15, R16 are independently
• hydrogen,
• alkyl, which is optionally substituted by one or more alkyl group substituents,
• aralkyl, wherein the aryl portion is optionally substituted by one or more ring system substituents and the alkyl portion is optionally substituted by one or more alkyl group substituents, or
• alkoxycarbonyl, wherein the alkyl portion is optionally substituted by one or more alkyl group substituents;
• or a pharmaceutically acceptable salt thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof,
• wherein
• alkyl is an aliphatic hydrocarbon group which is straight or branched having 1 to about 20 carbon atoms;
• aryl is an aromatic monocyclic or multicyclic ring system of about 6 to about 14 carbon atoms;
• a ring system substituent is halo, unsubstituted lower alkyl of 1 to about 4 carbon atoms, unsubstituted alkoxy, unsubstituted aryloxy, unsubstituted aralkyloxy or unsubstituted cycloalkylalkyloxy;
• and
• an alkyl group substituent is unsubstituted acyl, carboxyl, unsubstituted carboxymethyl, unsubstituted methoxycarbonylethyl, unsubstituted benzyloxycarbonylmethyl, unsubstituted pyridylmethyloxycarbonylmethyl or unsubstituted alkoxycarbonyl.